J.JarzembowskiJ
Iron supplementation was found to exacerbate disease activity and oxidative stress in a rat model of colitis induced by DSS ( 3.5 Regulatory mechanisms of ferroptosis in IBD Indeed, the molecular mechanisms of ferroptosis are diverse, and several transcription factors (e.g., TP53, NFE2L2/NRF2, ATF3, ATF4, YAPTAZTFAP2CSPHIFAEPAS/HIFA BACH TFEBJUNHIC1, and HNF4A) play multiple roles through transcription-dependent or transcription-independent mechanisms play multiple roles in shaping ferroptosis susceptibility (70)
doi: 10.3389/fmolb.2025.1724944 Received 14 October 2025 Revised 18 November 2025 Accepted 30 November 2025 Published 18 December 2025 Volume 12 - 2025 Edited by Maria Barile, University of Bari Aldo Moro, Italy Reviewed by Anna Maria Giudetti, University of Salento, Italy Maria Tolomeo, National Research Council (CNR), Italy Updates Copyright 2025 Schrder, Jalilvand, Kahl, Kaiser and Liebau
Enteroendocrine cells (EECs), the microbiota, and metabolites produced by the microbiota constitute a complex signaling system [13] that involves the enteric plexus, CNS afferents and efferents, and the modulation of numerous brain nuclei like the nucleus tractus solitarius, hypothalamus, thalamus, and many others directly involved in the control of glucose and energy homeostasis [14]
The move reflects a broader trend as employers weigh the benefits of obesity treatment against rising healthcare expenses, raising concerns that access to popular weight-loss drugs could become more limited despite strong patient demand
M., Piccolo, D